Progesterone-induced immunosuppression is not mediated through the progesterone receptor

Progesterone signaling mediated through progesterone receptor membrane component-1 in ovarian cells with special emphasis on ovarian cancer.

Various ovarian cell types including granulosa cells and ovarian surface epithelial cells express the progesterone (P4) binding protein, progesterone receptor membrane component-1 (PGRMC1). PGRMC1 is also expressed in ovarian tumors. PGRMC1 plays an essential role in promoting the survival of both normal and cancerous ovarian cell in vitro. Given the clinical significance of factors that regula...

Progesterone regulation of the progesterone receptor in rat gonadotropes.

For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms. Nuclear PR-immunoreactivity (PR-IR) in gonadotropes, identified by dual immunofluorescenc...

Progesterone receptor modulators.

The review1 on ‘Progesterone receptor modulators in gynaecological practice’ in the April 2010 issue of the Journal is a valuable contribution to the available literature on a currently important subject. In the section on ‘Contraception’ the authors have dealt at length with mifepristone. Since the latter is not licensed for postcoital contraception, it would have been appreciated if the autho...

INFORMATIONAL GUIDE PROGESTERONE METABOLITES PREMENOPAUSE Urinary Progesterone Metabolites in Premenopausal Women Not Supplementing with Progesterone

The urinary progestogen metabolites included in our profiles encompass the primary urinary metabolite, pregnanediol (Pgdiol), and four other more minor metabolites that belong to the pregnane (Allopregnanolone, Allo-pregnanediol) and pregnene (3α-dihydroprogesterone, 20α-dihydroprogesterone) categories. In postmenopausal women the level of pregnanediol is expected to be much lower than in preme...

Apoptosis Are Susceptible to Progesterone-Induced NK Cells Expressing a Progesterone Receptor